HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-iodopyridine → 2-(2-Chloro-pyridin-4-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-iodopyridine | HCID 1516511 | — |
| Reactant | HCID 57468602 | HCID 57468602 | — |
| Product | 2-(2-Chloro-pyridin-4-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 57468730 | — |
Reaction Steps
The title compound was prepared from 2-iodo-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.4) (1.47 g, 3.52 mmol) and commercially available 2-chloro-4-iodo-pyridine [CAS No. 153034-86-7] (860 mg 3.6 mmol) according to the general procedure IVc protocol a. Obtained as a light yellow solid (0.70 g, 49%). MS (ISP) 404.1 [(M+H)+]; mp 144.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-37aa1a3417cc49039e4ad64ed62ace88 |
| Source note | uspto-grants-2010_01 |