HCID 57468603, compound → HCID 57468731, compound

HRID 1989144Notes

Reaction equation

HRID 1989144 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH:8]([F:10])[F:9])[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[N:3]=1.[Br:21][C:22]1[N:23]=[CH:24][NH:25][CH:26]=1>>[Br:21][C:22]1[N:23]=[CH:24][N:25]([C:2]2[N:7]=[C:6]([CH:8]([F:10])[F:9])[CH:5]=[C:4]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)[N:3]=2)[CH:26]=1

Participants

3

Reactant 2

HCID 57468603HCID 57468603, compoundHCID 178418934HCID 178418934, compound

Product 1

HCID 57468731HCID 57468731, compound

Procedure

The title compound was prepared from 2-chloro-4-difluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.5) (1.0 g, 3.24 mmol) and commercially available 4-bromo-imidazole (0.71 g, 4.86 mmol) according to the general procedure IVa. Obtained as a light brown solid (0.98 g, 72%). MS (ISP) 420.9 [(M+H)+]; mp 147° C.

Sources & evidence

ORD record
ord-4794b91404c040fa9b1a7ec59b53edbe
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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