(3-Bromophenyl)boronic acid → HCID 57468732, compound

HRID 1989145Notes

Reaction equation

HRID 1989145 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH:8]([F:10])[F:9])[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[N:3]=1.[Br:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1>>[Br:21][C:22]1[CH:27]=[C:26]([C:2]2[N:7]=[C:6]([CH:8]([F:10])[F:9])[CH:5]=[C:4]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)[N:3]=2)[CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 57468603HCID 57468603, compound

Product 1

HCID 57468732HCID 57468732, compound

Procedure

The title compound was prepared from 2-chloro-4-difluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.5) (0.5 g, 1.62 mmol) and commercially available 3-bromo-benzene-boronic acid (0.42 g, 2.20 mmol) according to the general procedure IVb. Obtained as a white solid (0.54 g, 78%). MS (EI) 430.0 [(M)+]; mp 98.5° C.

Sources & evidence

ORD record
ord-86ae625e1d0f43308ca35f021fc7d883
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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