HCID 57468611, compound → HCID 57468733, compound

HRID 1989146Notes

Reaction equation

HRID 1989146 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([O:18][CH2:19][CH3:20])[CH:9]=2)[CH:5]=[C:4]([C:21]([F:24])([F:23])[F:22])[N:3]=1.[Br:25][C:26]1[N:27]=[CH:28][NH:29][CH:30]=1>>[Br:25][C:26]1[N:27]=[CH:28][N:29]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([O:18][CH2:19][CH3:20])[CH:9]=3)[CH:5]=[C:4]([C:21]([F:24])([F:23])[F:22])[N:3]=2)[CH:30]=1

Participants

3

Reactant 2

HCID 57468611HCID 57468611, compoundHCID 178418934HCID 178418934, compound

Product 1

HCID 57468733HCID 57468733, compound

Procedure

The title compound was prepared from 2-chloro-4-(3-ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine (example A.10) (0.5 g, 1.35 mmol) and commercially available 4-bromo-imidazole (0.30 g, 2.02 mmol) according to the general procedure IVa. Obtained as a white solid (0.47 g, 72%). MS (ISP) 483.0 [(M+H)+]; mp 147.5° C.

Sources & evidence

ORD record
ord-7aa5009a394a43cf891ca03f53fb90f4
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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