2-Chloro-4-iodopyridine → HCID 57468734, compound

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Reaction Steps

The title compound was prepared from 2-iodo-4-difluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.9) (0.43 g, 1.07 mmol) and commercially available 2-chloro-4-iodo-pyridine [CAS No. 153034-86-7] (263 mg, 1.1 mmol) according to the general procedure IVc protocol a. Obtained as an off-white solid (0.20 g, 48%). MS (ISP) 386.0 [(M+H)+]; mp 143.5° C.

Provenance & Evidence