HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromopyrazole → 2-(4-Bromo-pyrazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromopyrazole | HCID 16375 | — |
| Reactant | 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine | HCID 57468599 | — |
| Product | 2-(4-Bromo-pyrazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 57468735 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.2) (0.98 g, 3.0 mmol) and commercially available 4-bromopyrazole (0.66 g, 4.50 mmol) according to the general procedure IVa. Obtained as a white solid (0.83 g, 59%). MS (ISP) 437.0 [(M+H)+]; mp 175.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-baf4413c2b634c288b606983e4db9b19 |
| Source note | uspto-grants-2010_01 |