2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine → 2-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine

HRID 1989149Notes

Reaction equation

HRID 1989149 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:15])[N:3]=1.[Br:16][C:17]1[N:18]=[CH:19][NH:20][CH:21]=1>>[Br:16][C:17]1[N:18]=[CH:19][N:20]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=3)[CH:5]=[C:4]([CH3:15])[N:3]=2)[CH:21]=1

Participants

3

Reactant 2

HCID 202255702-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidineHCID 178418934HCID 178418934, compound

Product 1

HCID 574687362-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine (example A.11) (1.91 g, 8.0 mmol) and commercially available 4-bromo-imidazole (1.76 g, 12.0 mmol) according to the general procedure IVa. Obtained as a light brown solid (2.76 g, 98%). MS (ISP) 349.1 [(M+H)+]; mp 176-178° C.

Sources & evidence

ORD record
ord-1e3a7df8b3bd447fb8dec73698b4e2d7
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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