HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(4-chlorophenyl)-6-cyclopropylpyrimidine → 2-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(4-chlorophenyl)-6-cyclopropylpyrimidine | HCID 57468616 | — |
| Reactant | HCID 178418934 | HCID 178418934 | — |
| Product | 2-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine | HCID 57468738 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine (example A.13) (0.80 g, 3.0 mmol) and commercially available 4-bromo-imidazole (0.66 g, 4.50 mmol) according to the general procedure IVa. Obtained as a white solid (0.71 g, 63%). MS (ISP) 375.1 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-7e170d43e55f4e17b5b83ff2e5de967e |
| Source note | uspto-grants-2010_01 |