HCID 24901862, compound → HCID 57468739, compound

HRID 1989152Notes

Reaction equation

HRID 1989152 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.[Br:15][C:16]1[N:17]=[CH:18][NH:19][CH:20]=1>>[Br:15][C:16]1[N:17]=[CH:18][N:19]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=3)[CH:5]=[CH:4][N:3]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 24901862HCID 24901862, compoundHCID 178418934HCID 178418934, compound

Product 1

HCID 57468739HCID 57468739, compound

Procedure

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-pyrimidine (example A.14) (0.90 g, 4.0 mmol) and commercially available 4-bromo-imidazole (0.88 g, 6.0 mmol) according to the general procedure IVa. Obtained as a white solid (1.09 g, 81%). MS (ISP) 335.1 [(M+H)+]; mp 166-168° C.

Sources & evidence

ORD record
ord-6dc1fea1ecf64b029deb88fd51a8bd5a
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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