HCID 57468620, compound → HCID 57468743, compound

HRID 1989156Notes

Reaction equation

HRID 1989156 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:3]=1.[I:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:4]2[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=[C:2]([N:23]3[CH:24]=[C:20]([I:19])[N:21]=[CH:22]3)[N:3]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 57468620HCID 57468620, compoundHCID 178506559HCID 178506559, compound

Product 1

HCID 57468743HCID 57468743, compound

Procedure

The title compound was prepared 2-chloro-6-(4-chloro-phenyl)-4-trifluoromethyl-pyridine (example A.16) (10.14 g, 35 mmol) and commercially available 4-iodo-imidazole (8.081 g, 42 mmol) according to the general procedure IVa. Obtained as a white solid (2.80 g, 18%). MS (ISP) 450.0 [(M+H)+] and 452 [(M+2+H)+].

Sources & evidence

ORD record
ord-06db8b9055534915b1d3237cb5b39c27
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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