2-Chloro-4-iodopyridine → HCID 86615441, compound

HRID 1989164Notes

Reaction equation

HRID 1989164 reaction equation
Br[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[N:3]=1.[Cl:22][C:23]1[CH:28]=[C:27](I)[CH:26]=[CH:25][N:24]=1>C([Mg]Cl)(C)C.[Cl-].[Cl-].[Zn+2]>[Cl:22][C:23]1[CH:28]=[C:27]([C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=3)[N:3]=2)[CH:26]=[CH:25][N:24]=1

Participants

4

Reactant 2

HCID 15165112-Chloro-4-iodopyridineHCID 57468624HCID 57468624, compound

Product 1

HCID 86615441HCID 86615441, compound

Reagents, catalysts & solvents 1

HCID 178461731HCID 178461731, compoundCatalyst

Procedure

The title compound was prepared from 2-bromo-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyridine (example A.19) (1.11 g, 3.0 mmol), commercially available 2-chloro-4-iodo-pyridine [CAS No. 153034-86-7] (740 mg, 3.1 mmol) and i-PrMgCl/ZnCl2 according to the general procedure IVc protocol a. Obtained as a white solid (0.601 g, 50%). MS (ISP) 403.3 [(M+H)+] and 405.2 [(M+2+H)+].

Sources & evidence

ORD record
ord-e518a615b6324c01895e7d05914ecba0
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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