HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-iodopyridine → 2'-Chloro-6-cyclopropyl-4-(4-trifluoromethylphenyl)-[2,4']bipyridinyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-iodopyridine | HCID 1516511 | — |
| Reactant | Trifluoro-methanesulfonic acid 6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester | HCID 57468747 | — |
| Catalyst | HCID 178461731 | HCID 178461731 | — |
| Product | 2'-Chloro-6-cyclopropyl-4-(4-trifluoromethylphenyl)-[2,4']bipyridinyl | HCID 86615443 | — |
Reaction Steps
The title compound was prepared from trifluoro-methanesulfonic acid 6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester (example A.34) (2.7 g, 7.0 mmol), commercially available 2-chloro-4-iodo-pyridine [CAS No. 153034-86-7] (1.62 g, 6.8 mmol) and i-PrMgCl/ZnCl2 according to the general procedure IVc protocol a. Obtained as a white solid (0.75 g, 30%). MS (ISP) 375.2 [(M+H)+] and 377.1 [(M+2+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-f7521c22560f49d08cdeaaf7aae6f564 |
| Source note | uspto-grants-2010_01 |