2-Chloropyridine-4-boronic acid → HCID 57468763, compound

HRID 1989178Notes

Reaction equation

HRID 1989178 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Cl:19][C:20]1[CH:25]=[C:24](B(O)O)[CH:23]=[CH:22][N:21]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([C:2]2[N:3]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[CH:5]=[C:6]([CH3:8])[N:7]=2)[CH:23]=[CH:22][N:21]=1

Participants

3

Reactant 2

HCID 51515952-Chloropyridine-4-boronic acidHCID 574686142-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

Product 1

HCID 57468763HCID 57468763, compound

Procedure

The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)pyrimidine (example A.12) (0.27 g, 1.0 mmol) and commercially available 2-chloro-pyridine-4-boronic acid (0.21 g, 1.3 mmol) according to the general procedure IVb. Obtained as an off-white solid (0.175 g, 50%). MS (ISP) 350.4 [(M+H)+]; mp 147° C.

Sources & evidence

ORD record
ord-48139eff694141b99338a4db468db95c
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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