HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromophenyl)boronic acid → 2-(3-Bromophenyl)-4-(3-methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromophenyl)boronic acid | HCID 2734318 | — |
| Reactant | 2-Chloro-6-(3-methyl-4-trifluoromethyl-phenyl)-4-trifluoromethyl-pyrimidine | HCID 57468654 | — |
| Product | 2-(3-Bromophenyl)-4-(3-methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine | HCID 57468766 | — |
Reaction Steps
The title compound was prepared from 2-chloro-6-(3-methyl-4-trifluoromethyl-phenyl)-4-trifluoromethyl-pyrimidine (example A.38) (0.68 g, 2.0 mmol) and commercially available 3-bromo-benzene-boronic acid (0.44 g, 2.20 mmol) according to the general procedure IVb. Obtained as a white solid (0.23 g, 25%). MS (EI) 462.1 [(M)+]; mp 102.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-1a924a7e6d2f4d43b2aa857a5beae6f2 |
| Source note | uspto-grants-2010_01 |