(3-Bromophenyl)boronic acid → 2-(3-Bromo-phenyl)-4-(3,4-dichlorophenyl)-6-methyl-pyrimidine

HRID 1989194Notes

Reaction equation

HRID 1989194 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([CH3:16])[N:3]=1.[Br:17][C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][CH:23]=1>>[Br:17][C:18]1[CH:23]=[C:22]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=3)[CH:5]=[C:4]([CH3:16])[N:3]=2)[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 57468659HCID 57468659, compound

Product 1

HCID 574687762-(3-Bromo-phenyl)-4-(3,4-dichlorophenyl)-6-methyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-methyl-pyrimidine (example A.41) (0.4 g, 0.5 mmol) and commercially available 3-bromo-benzeneboronic acid (0.38 g, 1.89 mmol) according to the general procedure IVb. Obtained as an orange solid (0.23 g, 40%). MS (ISP) 394.9 [(M+H)+]; mp 132.5° C.

Sources & evidence

ORD record
ord-994fc6066003434fb406089b1be5f08f
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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