2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → HCID 57468778, compound

HRID 1989196Notes

Reaction equation

HRID 1989196 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Br:19][C:20]1[N:21]=[C:22]([CH3:25])[NH:23][CH:24]=1>>[Br:19][C:20]1[N:21]=[C:22]([CH3:25])[N:23]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 574686142-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidineHCID 178432450HCID 178432450, compound

Product 1

HCID 57468778HCID 57468778, compound

Procedure

The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)pyrimidine (example A.12) (0.4 g, 1.47 mmol) and commercially available 4-bromo-2-methylimidazole (0.35 g, 2.17 mmol) according to the general procedure IVa. Obtained as a light brown solid (0.41 g, 70%). MS (ISP) 399.0 [(M+H)+]; mp 180° C.

Sources & evidence

ORD record
ord-50c5d6d817a64699aa607745c9a317e0
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

Loading…