2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → 2-(3-Chloro-[1,2,4]triazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

HRID 1989197Notes

Reaction equation

HRID 1989197 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Cl:19][C:20]1[N:24]=[CH:23][NH:22][N:21]=1>>[Cl:19][C:20]1[N:24]=[CH:23][N:22]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[N:21]=1

Participants

3

Reactant 2

HCID 574686142-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidineHCID 178478410HCID 178478410, compound

Product 1

HCID 574687792-(3-Chloro-[1,2,4]triazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)pyrimidine (example A.12) (0.4 g, 1.47 mmol) and commercially available 3-chloro-1H-[1,2,4]triazole (0.22 g, 2.17 mmol) according to the general procedure IVa. Obtained as a yellow solid (0.36 g, 72%). MS (ISP) 340.0 [(M+H)+]; mp 137.5° C.

Sources & evidence

ORD record
ord-ebd34c890439482eb4134f98b8db2006
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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