HCID 57468663, compound → HCID 57468780, compound

HRID 1989198Notes

Reaction equation

HRID 1989198 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[N:3]=1.[Br:21][C:22]1[N:23]=[CH:24][NH:25][CH:26]=1>>[Br:21][C:22]1[N:23]=[CH:24][N:25]([C:2]2[N:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[C:4]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)[N:3]=2)[CH:26]=1

Participants

3

Reactant 2

HCID 57468663HCID 57468663, compoundHCID 178418934HCID 178418934, compound

Product 1

HCID 57468780HCID 57468780, compound

Procedure

The title compound was prepared from 2-chloro-4-isopropyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.43) (0.4 g, 1.33 mmol) and commercially available 4-bromo-imidazole (0.29 g, 2.0 mmol) according to the general procedure IVa. Obtained as an off-white solid (0.5 g, 91%). MS (ISP) 413.1 [(M+H)+]; mp 185° C.

Sources & evidence

ORD record
ord-9d1bd63830f94939996b3efd353aff37
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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