HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodo-5-methyl-1H-imidazole → 2-(4-Iodo-5-methyl-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodo-5-methyl-1H-imidazole | HCID 610310 | — |
| Reactant | 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine | HCID 57468599 | — |
| Product | 2-(4-Iodo-5-methyl-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 57468781 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.2) (0.33 g, 1.0 mmol) and commercially available 4-iodo-5-methyl-imidazole (0.25 g, 1.2 mmol) according to the general procedure IVa. Obtained as an off-white solid (0.43 g, 85%). MS (ISP) 498.8 [(M+H)+]; mp 202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-6c65394b79ca444b940771baf02aba58 |
| Source note | uspto-grants-2010_01 |