HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine → 4-(4-Chloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine | HCID 20225570 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 4-(4-Chloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyrimidine | HCID 57468783 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine (example A.11) (1.67 g, 7.0 mmol) and commercially available 4-iodo-imidazole (2.04 g, 10.5 mmol) according to the general procedure IVa. Obtained as a light yellow solid (1.97 g, 71%). MS (ISP) 397.1 [(M+H)+]; mp 184° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-976f5c182c824939a2da73062e3b1796 |
| Source note | uspto-grants-2010_01 |