HCID 4504275, compound → HCID 57468784, compound

HRID 1989202Notes

Reaction equation

HRID 1989202 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=1.[I:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=[C:2]([N:23]3[CH:24]=[C:20]([I:19])[N:21]=[CH:22]3)[N:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 4504275HCID 4504275, compoundHCID 178506559HCID 178506559, compound

Product 1

HCID 57468784HCID 57468784, compound

Procedure

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine (example A.1) (1.76 g, 6.0 mmol) and commercially available 4-iodo-imidazole (1.28 g, 6.6 mmol) according to the general procedure IVa. Obtained as an off-white (2.59 g, 96%). MS (ISP) 451.0 [(M+H)+]; mp 258° C.

Workup

  1. customObtained as an off-white (2.59 g, 96%)

Sources & evidence

ORD record
ord-db8c55e454354e20b366cf08fc8637df
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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