HCID 57468659, compound → 4-(3,4-Dichloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyrimidine

HRID 1989207Notes

Reaction equation

HRID 1989207 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([CH3:16])[N:3]=1.[I:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1>>[Cl:15][C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[C:4]([CH3:16])[N:3]=[C:2]([N:21]3[CH:22]=[C:18]([I:17])[N:19]=[CH:20]3)[N:7]=2)[CH:13]=[CH:12][C:11]=1[Cl:14]

Participants

3

Reactant 2

HCID 57468659HCID 57468659, compoundHCID 178506559HCID 178506559, compound

Product 1

HCID 574687894-(3,4-Dichloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-methyl-pyrimidine (example A.41) (3.83 g, 14.0 mmol) and commercially available 4-iodo-imidazole (4.07 g, 21.0 mmol) according to the general procedure IVa. Obtained as a brown solid (1.41 g, 24%). MS (ISP) 431.0 [(M+H)+]; mp 224.5° C.

Sources & evidence

ORD record
ord-5c34ae9606bb49aabaa1db8a1c444694
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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