HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(4-chloro-3-methyl-phenyl)-6-methyl-pyrimidine → 4-(4-Chloro-3-methyl-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(4-chloro-3-methyl-phenyl)-6-methyl-pyrimidine | HCID 57468670 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 4-(4-Chloro-3-methyl-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyrimidine | HCID 57468790 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-(4-chloro-3-methyl-phenyl)-6-methyl-pyrimidine (example A.47) (3.5 g, 13.8 mmol) and commercially available 4-iodo-imidazole (2.95 g, 15.2 mmol) according to the general procedure IVa. Obtained as an off-white solid (2.67 g, 92%). MS (ISP) 485.1 [(M+H)+]; mp 223° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-76c75d6f04f4494d821969434d66920d |
| Source note | uspto-grants-2010_01 |