HCID 57468667, compound → HCID 57468793, compound

HRID 1989211Notes

Reaction equation

HRID 1989211 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=1.[I:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=[C:2]([N:23]3[CH:24]=[C:20]([I:19])[N:21]=[CH:22]3)[N:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 57468667HCID 57468667, compoundHCID 178506559HCID 178506559, compound

Product 1

HCID 57468793HCID 57468793, compound

Procedure

The title compound was prepared from 2-chloro-4-(4-fluoro-phenyl)-6-trifluoromethyl-pyrimidine (example A.45) (1.5 g, 5.4 mmol) and commercially available 4-iodo-imidazole (1.58 g, 8.15 mmol) according to the general procedure IVa. Obtained as a white solid (2.23 g, 95%). MS (ISP) 435.0 [(M+H)+]; mp 235° C.

Sources & evidence

ORD record
ord-7b48f008dee3401d826a343ace37bdb2
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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