HCID 57468713, compound → HCID 24760287, compound

HRID 1989276Notes

Reaction equation

HRID 1989276 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][OH:9])=[NH:7])=[CH:4][N:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[N:22]=[C:21]([C:29](O)=O)[N:20]=2)=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:24]=[C:23]([C:25]([F:27])([F:26])[F:28])[N:22]=[C:21]([C:29]3[O:9][N:8]=[C:6]([C:5]4[CH:10]=[CH:11][C:2]([NH2:1])=[N:3][CH:4]=4)[N:7]=3)[N:20]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 57468713HCID 57468713, compoundHCID 178513347HCID 178513347, compound

Product 1

HCID 24760287HCID 24760287, compound

Procedure

The title compound was prepared from 6-amino-N-hydroxy-nicotinamidine (example C.3) (0.15 g, 1.0 mmol) and 4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.1) (0.15 g, 0.5 mmol) according to the general procedure V. Obtained as a light brown solid (0.05 g, 24%). MS (ISP) 419.0 [(M+H)+]; mp 211° C.

Sources & evidence

ORD record
ord-df1dfa5d7f024fad90b9eba26a5c4bba
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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