6-Aminonicotinic acid → HCID 60209354, compound

HRID 1989288Notes

Reaction equation

HRID 1989288 reaction equation
[OH:1][NH:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[N:6]=1)=[NH:4].[NH2:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](O)=O)=[CH:28][N:27]=1>>[F:14][C:11]([F:12])([F:13])[C:9]1[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=2)[N:6]=[C:5]([C:3]2[N:4]=[C:30]([C:29]3[CH:33]=[CH:34][C:26]([NH2:25])=[N:27][CH:28]=3)[O:1][N:2]=2)[N:10]=1

Participants

3

Reactant 2

HCID 184966-Aminonicotinic acidHCID 178513396HCID 178513396, compound

Product 1

HCID 60209354HCID 60209354, compound

Procedure

The title compound was prepared from N-hydroxy-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-carboxamidine (example C.2) (0.176 g, 0.5 mmol) and commercially available 6-amino-nicotinic acid (0.07 g, 0.5 mmol) according to the general procedure V. Obtained as an off-white solid (0.055 g, 24%). MS (ISP) 453.1 [(M+H)+]; mp 205° C.

Sources & evidence

ORD record
ord-175ce0609d6a44c3a58cd29ea5b8c71b
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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