HCID 57468713, compound → HCID 24760213, compound

HRID 1989296Notes

Reaction equation

HRID 1989296 reaction equation
[OH:1][NH:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)=[NH:4].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[N:21]=[C:20]([C:28](O)=O)[N:19]=2)=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[C:22]([C:24]([F:26])([F:25])[F:27])[N:21]=[C:20]([C:28]3[O:1][N:2]=[C:3]([C:5]4[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=4)[N:4]=3)[N:19]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 57468713HCID 57468713, compoundHCID 178513339HCID 178513339, compound

Product 1

HCID 24760213HCID 24760213, compound

Procedure

The title compound was prepared from available N-hydroxy-3-pyridinecarboxamidine [CAS-No. 1594-58-7] (0.103 g, 0.75 mmol) and 4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.1) (0.15 g, 0.5 mmol) according to the general procedure V. Obtained as a yellow solid (0.092 g, 46%). MS (ISP) 404.4 [(M+H)+]; mp 168.5° C.

Sources & evidence

ORD record
ord-15f3f95e64a2495f833d35a7bf4d3f95
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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