3-Pyridinylboronic acid → HCID 57468598, compound

HRID 1989322Notes

Reaction equation

HRID 1989322 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([N:18]3[CH:22]=[C:21](I)[N:20]=[CH:19]3)[N:9]=2)=[CH:4][CH:3]=1.[N:24]1[CH:29]=[CH:28][CH:27]=[C:26](B(O)O)[CH:25]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([N:18]3[CH:22]=[C:21]([C:26]4[CH:25]=[N:24][CH:29]=[CH:28][CH:27]=4)[N:20]=[CH:19]3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 57468743HCID 57468743, compound

Product 1

HCID 57468598HCID 57468598, compound

Procedure

The title compound was prepared from 2-(4-chloro-phenyl)-6-(4-iodo-imidazol-1-yl)-4-trifluoromethyl-pyridine (example E.19) (0.45 g, 1.0 mmol) and commercially available 3-pyridineboronic acid (0.32 g, 2.6 mmol) according to the general procedure VI. Obtained as a white solid (0.011 g, 3%). MS (ISP) 401.2 [(M+H)+] and 403 [(M+2+H)+].

Sources & evidence

ORD record
ord-48abf4d436b94386825230fc820b22e5
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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