HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinylboronic acid → 2-Cyclopropyl-6-(3-pyridin-3-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | 2-(3-Bromo-phenyl)-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57468746 | — |
| Product | 2-Cyclopropyl-6-(3-pyridin-3-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57468867 | — |
Reaction Steps
The title compound was prepared from 2-(3-bromo-phenyl)-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine (example E.22) (0.392 g, 0.72 mmol) and commercially available 3-pyridineboronic acid (0.115 g, 0.93 mmol) according to the general procedure VI. Obtained as a white solid (0.120 g, 40%). MS (ISP) 417.3 [(M+H)+]; mp 100-104° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-4c075590d82b4d7f8b4eae64231989e3 |
| Source note | uspto-grants-2010_01 |