3-Pyridinylboronic acid → HCID 68692507, compound

HRID 1989348Notes

Reaction equation

HRID 1989348 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10]([C:18]3[CH:23]=[CH:22][N:21]=[C:20](Cl)[CH:19]=3)[N:9]=2)=[CH:4][CH:3]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27](B(O)O)[CH:26]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:15])[F:16])[N:11]=[C:10]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([C:27]4[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=4)[CH:19]=3)[N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 57468729HCID 57468729, compound

Product 1

HCID 68692507HCID 68692507, compound

Procedure

The title compound was prepared from 4-(4-chloro-phenyl)-2-(2-chloro-pyridin-4-yl)-6-trifluoromethyl-pyrimidine (example E.5) (0.185 g, 0.5 mmol) and commercially available 3-pyridineboronic acid (0.08 g, 0.65 mmol) according to the general procedure VI. Obtained as a white solid (0.018 g, 9%). MS (ISP) 413.1 [(M+H)+]; mp 226° C.

Sources & evidence

ORD record
ord-e2f3d76f431d49a0a454b22268b99313
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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