N-hydroxy-4-sulfamoylbenzene-1-carboximidamide → HCID 57468870, compound

HRID 1989353Notes

Reaction equation

HRID 1989353 reaction equation
[OH:1][NH:2][C:3](=[NH:14])[C:4]1[CH:9]=[CH:8][C:7]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:6][CH:5]=1.[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([C:28]2[CH:33]=[C:32]([C:34]([F:37])([F:36])[F:35])[N:31]=[C:30]([C:38](O)=O)[N:29]=2)[CH:21]=[CH:22][C:23]=1[C:24]([F:27])([F:26])[F:25])[CH3:16]>>[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([C:28]2[CH:33]=[C:32]([C:34]([F:36])([F:37])[F:35])[N:31]=[C:30]([C:38]3[O:1][N:2]=[C:3]([C:4]4[CH:9]=[CH:8][C:7]([S:10]([NH2:11])(=[O:12])=[O:13])=[CH:6][CH:5]=4)[N:14]=3)[N:29]=2)[CH:21]=[CH:22][C:23]=1[C:24]([F:25])([F:26])[F:27])[CH3:16]

Participants

3

Reactant 2

HCID 612025N-hydroxy-4-sulfamoylbenzene-1-carboximidamideHCID 57468716HCID 57468716, compound

Product 1

HCID 57468870HCID 57468870, compound

Procedure

The title compound was prepared from N-hydroxy-4-sulfamoyl-benzamidine [CAS-No. 4476-10-2] (0.16 g, 0.75 mmol) and 4-(3-ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.4) (0.19 g, 0.5 mmol) according to the general procedure V. Obtained as a light yellow solid (0.114 g, 41%). MS (ISP) 560.2 [(M+H)+]; mp 250.5° C.

Sources & evidence

ORD record
ord-498fca05f3d744afb1d2836e40096706
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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