2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine → HCID 57468881, compound

HRID 1989406Notes

Reaction equation

HRID 1989406 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[N:3]=1.[NH:22]1[CH:26]=[N:25][C:24]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)=[N:23]1>>[N:30]1[CH:29]=[CH:28][C:27]([C:24]2[N:25]=[CH:26][N:22]([C:2]3[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]4[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=4)[N:3]=3)[N:23]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 574685992-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidineHCID 178420001HCID 178420001, compound

Product 1

HCID 57468881HCID 57468881, compound

Procedure

The title compound was prepared from 2-chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example A.2) (0.16 g, 0.5 mmol) and 4-(1H-[1,2,4]-triazol-3-yl)-pyridine [CAS-No. 14803-99-7] (0.075 g, 0.51 mmol) according to the general procedure IVa. Obtained as a white solid (0.096 g, 44%). MS (ISP) 437.3 [(M+H)+]; mp 248° C.

Sources & evidence

ORD record
ord-34be2dae744448908d8809083c9705d6
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

Loading…