3-Nitrophenylboronic Acid → HCID 57468992, compound

HRID 1989523Notes

Reaction equation

HRID 1989523 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[N+:28]([C:31]1[CH:32]=[C:33](B(O)O)[CH:34]=[CH:35][CH:36]=1)([O-:30])=[O:29]>>[N+:28]([C:31]1[CH:36]=[C:35]([C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([C:8]3[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]4[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:23]=4)[N:9]=3)[CH:3]=2)[CH:34]=[CH:33][CH:32]=1)([O-:30])=[O:29]

Participants

3

Reactant 2

HCID 16773-Nitrophenylboronic AcidHCID 574687272-(3-Bromo-phenyl)-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine

Product 1

HCID 57468992HCID 57468992, compound

Procedure

2-(3′-Nitro-biphenyl-3-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)pyrimidine was prepared from 2-(3-bromo-phenyl)-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine (example E.3) (1.79 g, 4.0 mmol) and commercially available 3-nitrophenylboronic acid (0.8 g, 4.8 mmol) according to the general procedure VI. Obtained as a light grey solid (1.74 g, 89%). MS (EI) 489.2 [(M)+]; mp 219° C.

Sources & evidence

ORD record
ord-9010c1bb482d47e2a1ed891c4e9dc759
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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