HCID 57468724, compound → HCID 24760434, compound

HRID 1989545Notes

Reaction equation

HRID 1989545 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][OH:9])=[NH:7])=[CH:4][N:3]=1.[F:12][C:13]([F:34])([F:33])[C:14]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)[N:17]=[C:16]([C:30](O)=O)[CH:15]=1>>[F:34][C:13]([F:12])([F:33])[C:14]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=2)[N:17]=[C:16]([C:30]2[O:9][N:8]=[C:6]([C:5]3[CH:10]=[CH:11][C:2]([NH2:1])=[N:3][CH:4]=3)[N:7]=2)[CH:15]=1

Participants

3

Reactant 2

HCID 57468724HCID 57468724, compoundHCID 178513347HCID 178513347, compound

Product 1

HCID 24760434HCID 24760434, compound

Procedure

The title compound was prepared from 6-amino-N-hydroxy-nicotinamidine (example C.3) (0.128 g, 0.60 mmol) and 4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid (example D.12) (0.135 g, 0.403 mmol) according to the general procedure V. Obtained as a light yellow solid (0.022 g, 12%). MS (ISP) 452.1 [(M+H)+]; mp 229° C.

Sources & evidence

ORD record
ord-023568d19e7b4d449da00899d88d3a19
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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