(5-Sulfamoylpyridin-3-yl)boronic acid → HCID 57469012, compound

HRID 1989555Notes

Reaction equation

HRID 1989555 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[CH:11]=[C:10]([CH3:24])[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[S:25]([C:29]1[CH:30]=[N:31][CH:32]=[C:33](B(O)O)[CH:34]=1)(=[O:28])(=[O:27])[NH2:26]>>[CH3:24][C:10]1[N:9]=[C:8]([C:4]2[CH:3]=[C:2]([C:33]3[CH:34]=[C:29]([S:25]([NH2:26])(=[O:28])=[O:27])[CH:30]=[N:31][CH:32]=3)[CH:7]=[CH:6][CH:5]=2)[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 57415702(5-Sulfamoylpyridin-3-yl)boronic acidHCID 574687452-(3-Bromo-phenyl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 57469012HCID 57469012, compound

Procedure

The title compound was prepared from 2-(3-bromo-phenyl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example E.21) (0.200 g, 0.51 mmol) and 3-sulfamoyl-pyridine-5-boronic acid (example F.3) (0.103 g, 0.51 mmol) according to the general procedure VI. Obtained as a white solid (0.015 g, 6%). MS (ISP) 470.3 [(M+H)+]; mp>250° C.

Sources & evidence

ORD record
ord-54635270fac44e06842acd5419ddd74b
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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