2,4-Dibromo-1,3-thiazole → HCID 57469013, compound

HRID 1989558Notes

Reaction equation

HRID 1989558 reaction equation
I[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:18])[N:3]=1.Br[C:20]1[S:21][CH:22]=[C:23](Br)[N:24]=1>>[CH3:18][C:4]1[CH:5]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([F:16])([F:15])[F:17])=[CH:12][CH:13]=2)[CH:7]=[C:2]([C:20]2[S:21][CH:22]=[CH:23][N:24]=2)[N:3]=1

Participants

3

Reactant 2

HCID 27632972,4-Dibromo-1,3-thiazoleHCID 574686452-Iodo-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine

Product 1

HCID 57469013HCID 57469013, compound

Procedure

The title compound was prepared from 2-iodo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example A.31) (4.0 g, 9.36 mmol) and commercially available 2,4-dibromothiazole (2.53 g, 10.4 mmol) according to the general procedure IVc protocol b. Obtained as a side product as a light yellow solid (0.065 g, 2%). MS (ISP) 321.2 [(M+H)+]; mp 103° C.

Sources & evidence

ORD record
ord-72ba295a34474c808bf19ccd7d72283b
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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