5-Bromo-2-thiophenesulfonamide → HCID 57469019, compound

HRID 1989578Notes

Reaction equation

HRID 1989578 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10](B(O)O)[CH:11]=[CH:12][CH:13]=2)[CH:5]=[C:4]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[CH:3]=1.Br[C:28]1[S:32][C:31]([S:33]([NH2:36])(=[O:35])=[O:34])=[CH:30][CH:29]=1>>[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([C:28]3[S:32][C:31]([S:33]([NH2:36])(=[O:35])=[O:34])=[CH:30][CH:29]=3)[CH:11]=[CH:12][CH:13]=2)[CH:5]=[C:4]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 12413045-Bromo-2-thiophenesulfonamideHCID 602093413-[6-Methyl-4-(4-trifluoromethyl-phenyl)pyridin-2-yl]-benzeneboronic acid

Product 1

HCID 57469019HCID 57469019, compound

Procedure

The title compound was prepared from 3-[6-methyl-4-(4-trifluoromethyl-phenyl)pyridin-2-yl]-benzeneboronic acid (example G.9) (0.40 g, 1.1 mmol) and commercially available 5-bromo-thiophene-2-sulfonic acid amide (0.478 g, 2.4 mmol) according to the general procedure VI. Obtained as a white solid (0.180 g, 42%). MS (ISP) 475.2 [(M+H)+]; mp 215° C.

Sources & evidence

ORD record
ord-400081b08d4c4214877b5b1384e19215
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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