5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → HCID 68690012, compound

HRID 1989583Notes

Reaction equation

HRID 1989583 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:15]=[C:14]([CH3:16])[N:13]=[C:12]([C:17]4[CH:22]=[CH:21][CH:20]=[C:19](Br)[CH:18]=4)[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.[NH2:24][C:25]1[CH:30]=[CH:29][C:28](B2OC(C)(C)C(C)(C)O2)=[CH:27][N:26]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:15]=[C:14]([CH3:16])[N:13]=[C:12]([C:17]4[CH:18]=[C:19]([C:28]5[CH:29]=[CH:30][C:25]([NH2:24])=[N:26][CH:27]=5)[CH:20]=[CH:21][CH:22]=4)[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 68689698HCID 68689698, compound

Product 1

HCID 68690012HCID 68690012, compound

Procedure

The title compound was prepared from 4-benzo[1,3]dioxol-5-yl-2-(3-bromo-phenyl)-6-methyl-pyridine (example E.91) (0.150 g, 0.407 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.099 g, 0.448 mmol) according to the general procedure VI. Obtained as a white solid (0.100 g, 64%). MS (ISP) 382.2 [(M+H)+]; mp 203° C.

Sources & evidence

ORD record
ord-e19f8664f02d4d0b886ea83a6ec1cbd0
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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