3-(Methylsulfonyl)phenylboronic acid → HCID 68689569, compound

HRID 1989662Notes

Reaction equation

HRID 1989662 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[CH:11]=[C:10]([CH3:24])[N:9]=2)[CH:5]=[CH:4][CH:3]=1.[CH3:25][S:26]([C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[CH:33][CH:34]=1)(=[O:28])=[O:27]>>[CH3:25][S:26]([C:29]1[CH:34]=[C:33]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[C:12]([C:14]4[CH:15]=[CH:16][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:18][CH:19]=4)[CH:11]=[C:10]([CH3:24])[N:9]=3)[CH:5]=[CH:4][CH:3]=2)[CH:32]=[CH:31][CH:30]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 866154406'-Bromo-6-methyl-4-(4-trifluoromethylphenyl)-[2,2']bipyridinyl

Product 1

HCID 68689569HCID 68689569, compound

Procedure

The title compound was prepared from 6′-bromo-6-methyl-4-(4-trifluoromethylphenyl)-[2,2′]bipyridinyl (example E.26) (0.39 g, 1.1 mmol) and commercially available (3-methylsulfonylphenyl)boronic acid (0.218 g, 1.0 mmol) according to the general procedure VI. Obtained as a white solid (0.420 g, 90%). MS (ISP) 469.1 [(M+H)+]; mp 186° C.

Sources & evidence

ORD record
ord-13814129c9fe4366b1e883b3c4bbebc4
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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