3-(tert-Butylaminosulphonyl)benzeneboronic acid → HCID 57469120, compound

HRID 1989780Notes

Reaction equation

HRID 1989780 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[C:20]([O:28][CH2:29][CH3:30])[CH:19]=3)[N:9]=2)[CH:5]=[CH:4][N:3]=1.[C:31]([NH:35][S:36]([C:39]1[CH:40]=[C:41](B(O)O)[CH:42]=[CH:43][CH:44]=1)(=[O:38])=[O:37])([CH3:34])([CH3:33])[CH3:32]>>[C:31]([NH:35][S:36]([C:39]1[CH:40]=[CH:41][CH:42]=[C:43]([C:2]2[CH:7]=[C:6]([C:8]3[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[C:20]([O:28][CH2:29][CH3:30])[CH:19]=4)[N:9]=3)[CH:5]=[CH:4][N:3]=2)[CH:44]=1)(=[O:38])=[O:37])([CH3:34])([CH3:32])[CH3:33]

Participants

3

Reactant 2

HCID 441195383-(tert-Butylaminosulphonyl)benzeneboronic acidHCID 57468751HCID 57468751, compound

Product 1

HCID 57469120HCID 57469120, compound

Procedure

N-tert-Butyl-3-{4-[6-(3-ethoxy-4-trifluoromethyl-phenyl)-4-trifluoromethyl-pyrimidin-2-yl]-pyridin-2-yl}-benzenesulfonamide was prepared from 2-(2-chloro-pyridin-4-yl)-6-(3-ethoxy-4-trifluoromethyl-phenyl)-4-trifluoromethyl-pyrimidine (example E.108) (0.185 g, 0.41 mmol) and commercially available 3-(tert.-butylsulfamoyl)-phenylboronic acid (0.13 g, 0.50 mmol) according to the general procedure VI. Obtained as an off-white solid (0.24 g), which was subsequently deprotected.

Sources & evidence

ORD record
ord-b2b086c5bee34f939a03a1d37f1b181a
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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