Trifluoroacetic acid → HCID 57469126, compound

Participants

Reaction Steps

To a cooled and stirred solution of N-tert-butyl-3-{4-[4-difluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-pyridin-2-yl}-benzenesulfonamide (0.37 g) in dichloromethane (5 ml) was added TFA (5 ml) and the reaction mixture was allowed to stir at room temperature for 15 h. The mixture was evaporated to dryness, poured into 2N Na2CO3 solution (20 ml) and extracted with ethyl acetate (3×50 ml). The combined organic layers were washed with brine (50 ml), dried (MgSO4) and evaporated. Further purification by flash chromatography (heptane/ethyl acetate) and crystallization (dichloromethane/MeOH/hexane) yielded the title compound as an off-white solid (0.17 g, 34%). MS (ISP) 507.2 [(M+H)+]; mp 233.5° C.

Provenance & Evidence