Cyclopropanemethanamine → HCID 68523189, compound

Participants

Reaction Steps

O-benzotriazol-1-yl-tetramethyluronium hexafluorophosphate (89 mg, 0.235 mmol) was added to a solution of 6-amino-9-benzyl-8-methoxy-8,9-dihydro-7H-purine-2-carboxylic acid (Example 246) (64 mg, 0.214 mmol) and diisopropylethylamine (75 μl, 0.428 mmol) in dimethylacetamide (0.5 ml) and the reaction mixture stirred at room temperature for 1 hour. Aminomethylcyclopropane (28 μl, 0.321 mmol) was added and the reaction mixture stirred at room temperature for a further 20 hours. The reaction mixture was concentrated in vacuo and water added. The resultant precipitate was collected by filtration, azeotroped with toluene and triturated with methanol to yield the title compound.

Provenance & Evidence