HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 85888956, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 2838321 | HCID 2838321 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 85888956 | HCID 85888956 | 28% |
Reaction Steps
A solution of 1-biphenyl-4-ylmethyl-4-methyl-piperazine (26 mmol) in diethyl ether (50 mL) was added n-BuLi (38 mmol) and DMF (15 mL) and was refluxed for 6 h. The reaction was cooled and added 2 N NaOH (50 mL) and extracted with diethyl ether. Evaporation in vacuo gave a black oil that was purified by flash chromatography. Yield: 28% as black oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642367B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-000ed9ecc40e4bb687ad523642949511 |
| Source note | uspto-grants-2010_01 |