HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 10120773, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| Reactant | 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-(piperazinyl)-phenyl]-amide | HCID 11201099 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10120773 | HCID 10120773 | 83.2% |
Reaction Steps
A mixture of intermediate (2) (0.007 mol) and Na2CO3 (0.007 mol) in DMF (50 ml) was stirred. Methyl 2-bromo-2-phenylacetate (0.007 mol) was added dropwise. The mixture was stirred for 4 hours. The solvent was evaporated. The residue was dissolved in DCM. The organic layer was separated, washed, dried, filtered and the solvent was evaporated. The residue was triturated in 2-propanol. The precipitate was filtered off and dried, yielding 3.34 g of methyl α-phenyl-4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]phenyl]-1-piperazineacetate (intermediate 3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642378B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-72da7684fd0847ed92a072950fe64e2e |
| Source note | uspto-grants-2010_01 |