HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → Piperazin-1-yl-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| Reactant | 4-(Piperazin-1-yl)benzonitrile | HCID 2733995 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Piperazin-1-yl-acetic acid | HCID 650402 | 183.8% |
Reaction Steps
Methyl 2-bromo-2-phenylacetate (0.1 mol) was added dropwise to a mixture of 4-(1-piperazinyl)benzonitrile (0.1 mol) and Na2CO3 (90.15 mol) in DMF (250 ml), stirred at room temperature. The reaction mixture was stirred overnight. The solvent was evaporated. The residue was dissolved in DCM, washed, dried, filtered and the solvent evaporated. The residue was triturated under DIPE, filtered off and dried, yielding 26.5 g of 1-piperazineacetic acid, 4-(4-cyanophenyl)-α-phenyl-, methyl ester (intermediate 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642378B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-73802eaff36543358303b3369bad7838 |
| Source note | uspto-grants-2010_01 |