Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Piperidineacetonitrile, α-phenyl-, hydrochloride (1:1) | HCID 22252850 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22499375 | HCID 22499375 | 66.6% |
Reaction Steps
A mixture of α-phenyl-4-piperidineacetonitrile monohydrochloride (0.05 mol), 1-fluoro-4-nitrobenzene (0.06 mol) and K2CO3 (0.15 mol) in DMF (200 ml) was stirred at 50° C. for 4 hours, cooled, poured out into water and extracted with DCM. The organic layer was separated, washed with water, dried, filtered and the solvent was evaporated. The residue was crystallized from DIPE. The precipitate was filtered off and dried, yielding 10.7 g of (±)-1-(4-nitrophenyl)-α-phenyl-4-piperidineacetonitrile (intermediate 15, mp. 118° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07642378B2 |
|---|
| Source dataset | uspto-grants-2010_01 |
|---|
| ORD ID | ord-98bae33066d14d878cd9174e12bf4191 |
|---|
| Source note | uspto-grants-2010_01 |
|---|
