Thiophene → (+/-)-Methyl 1-(4-aminophenyl)-alpha-phenyl-4-piperidineacetate

Participants

Reaction Steps

A mixture of intermediate (17) (0.0022 mol) in methanol (100 ml) was hydrogenated at 50° C. with palladium on carbon (10%; 0.1 g) as a catalyst in the presence of a thiophene solution (4%; 0.1 ml). After uptake of hydrogen (3 equivalents), the catalyst was filtered off and the filtrate was evaporated. The residue was triturated in hexane. The precipitate was filtered off and dried, yielding 0.7 g (±)-methyl 1-(4-aminophenyl)-α-phenyl-4-piperidineacetate (intermediate 18, mp. 125° C.).

Provenance & Evidence