Acetone → 1-[4-(4-{5-[2-(allyloxy)phenyl]-4,5-dihydro-1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanone
Reaction equation
[C:38](=[O:39])([O-:40])[O-:41].[CH2:44]([CH:45]=[CH2:46])[Br:47].[CH3:49][C:50](=[O:51])[CH3:52].[F:1][CH:2]([c:3]1[n:4][n:5]([CH2:11][C:12](=[O:13])[N:14]2[CH2:15][CH2:16][CH:17]([c:20]3[s:21][cH:22][c:23]([C:25]4=[N:26][O:27][CH:28]([c:30]5[c:31]([OH:36])[cH:32][cH:33][cH:34][cH:35]5)[CH2:29]4)[n:24]3)[CH2:18][CH2:19]2)[c:6]([CH:8]([F:9])[F:10])[cH:7]1)[F:37].[K+:42].[K+:43].[OH2:48]>>[F:1][CH:2]([c:3]1[n:4][n:5]([CH2:11][C:12](=[O:13])[N:14]2[CH2:15][CH2:16][CH:17]([c:20]3[s:21][cH:22][c:23]([C:25]4=[N:26][O:27][CH:28]([c:30]5[c:31]([O:36][CH2:46][CH:45]=[CH2:44])[cH:32][cH:33][cH:34][cH:35]5)[CH2:29]4)[n:24]3)[CH2:18][CH2:19]2)[c:6]([CH:8]([F:9])[F:10])[cH:7]1)[F:37]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-8c54fbd27f614d9eb6ec2d08b27a27af
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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