反应详情

A solution of N-(1,5-dimethyl-1H-pyrazol-3-yl)-3-{[2-fluoro-1-(fluoromethyl)ethyl]oxy}-5-[(phenylmethyl)oxy]benzamide (1.89 mmol) in ethanol (30 mL) was treated with 10% palladium on carbon (78 mg, wetted with 1 mL ethanol). The flask was evacuated and filled with hydrogen and this procedure repeated a further 4 times. The mixture was left to stir at RT overnight under an atmosphere of hydrogen then the mixture filtered through Celite® and the cake washed with ethanol (50 mL) and ethyl acetate (50 mL). The combined organics were evaporated in vacuo to give the desired compound as a white foam (613 mg).

1. customThe flask was evacuated
2. additionfilled with hydrogen
3. waitThe mixture was left
4. filtrationthe mixture filtered through Celite®
5. washthe cake washed with ethanol (50 mL) and ethyl acetate (50 mL)
6. customThe combined organics were evaporated in vacuo