HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1990074Generated: November 1, 2026
N-bromobutanimide → tert-Butyl (2-bromothiophen-3-yl)carbamate
https://huagongshe.com/reaction/1990074
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | tert-butyl N-(thiophen-3-yl)carbamate | HCID 736476 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl (2-bromothiophen-3-yl)carbamate | HCID 13164363 | — |
Reaction Steps
Add NBS (8.9 g, 0.05 mol) to a boiling solution of 3-thiophenyl-carbamic acid tert-butyl ester (10.0 g, 0.05 mol) in dichloromethane (500 mL) in small portions and stir the mixture at 65° C. for 20 min. Cool down, remove solvent in vacuo and purify the crude material by flash chromatography (silica gel) eluting with hexanes/diethyl ether 19:1 to obtain 11.1 g (80%) as a white solid: 1H NMR (CDCl3) δ: 7.55 (br s, 1H), 7.24 (d, J=4.0 Hz, 1H), 6.56 (br s, 1H), 1.52 (s, 9H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07642361B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-8299d3cf9c394f2e8226ca6558f7a1a1 |
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| Source note | uspto-grants-2010_01 |
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